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Updated: Jun 22, 2026

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
08:13

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

[Cardiac diffusion MRI of recent and chronic myocardial infarction: preliminary results]

J P Laissy1, J M Serfaty, D Messika-Zeitoun

  • 1Département de Radiologie, AP-HP, Hôpital Bichat, 75018 Paris. jean-pierre.laissy@bch.aphp.fr

Journal De Radiologie
|June 9, 2009
PubMed
Abstract

Insights

Diffusion-weighted MR imaging (DWI) shows promise for diagnosing recent myocardial infarction (MI). This technique identified acute MI in patients, differentiating it from chronic conditions, aiding clinical detection.

Area of Science:

  • Cardiovascular Imaging
  • Magnetic Resonance Imaging
  • Diagnostic Techniques

Background:

  • Myocardial infarction (MI) diagnosis relies on various imaging modalities.
  • Diffusion-weighted imaging (DWI) is a sensitive technique for detecting tissue changes, commonly used in stroke patients.

Purpose of the Study:

  • To evaluate the utility of diffusion-weighted MR imaging (DWI) for diagnosing myocardial infarction (MI).
  • To assess if DWI can differentiate recent MI from chronic MI and other cardiac conditions.

Main Methods:

  • Developed and applied a breath-hold ECG-gated DWI sequence (b = 300 sec/mm2).
  • Studied 7 patients with recent MI, 3 with chronic MI, and 4 controls with valvular heart disease.
  • Correlated DWI findings with T2-weighted, first-pass perfusion, and delayed enhancement MRI data.

Main Results:

  • DWI revealed increased signal intensity and reduced apparent diffusion coefficient (ADC) in recent MI areas compared to normal myocardium.
  • Hyperintense lesions on DWI corresponded with areas of delayed gadolinium enhancement.
  • Diffusion images were normal in patients with chronic MI and in control subjects.

Conclusions:

  • Preliminary findings suggest DWI can aid clinicians in detecting recent myocardial infarction.
  • Further validation with reference methods and larger cohorts is warranted.

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