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Local C-reactive protein expression in obliterative lesions and the bronchial wall in posttransplant obliterative

Outi E Päiväniemi1, Paula K Maasilta, Tiina L S Vainikka

  • 1Department of Cardiothoracic Surgery, Helsinki University Hospital, P.O. Box 340, 00029 Helsinki, Finland. outi.paivaniemi@uta.fi

Mediators of Inflammation
|June 9, 2009
PubMed

The local immunoreactivity of C-reactive protein (CRP) was studied in a heterotopic porcine model of posttranplant obliterative bronchiolitis (OB). Bronchial allografts and control autografts were examined serially 2-28 days after subcutaneous transplantation. The autografts stayed patent. In the allografts, proliferation of inflammatory cells (P < .0001) and fibroblasts (P = .02) resulted in occlusion of the bronchial lumens (P < .01). Influx of CD4+ (P < .001) and CD8+ (P < .0001) cells demonstrated allograft immune response. CRP positivity simultaneously increased in the bronchial walls (P < .01), in macrophages, myofibroblasts, and endothelial cells. Local CRP was predictive of features characteristic of OB (R = 0.456-0.879, P < .05-P < .0001). Early obliterative lesions also showed CRP positivity, but not mature, collagen-rich obliterative plugs (P < .05). During OB development, CRP is localized in inflammatory cells, myofibroblasts and endothelial cells probably as a part of the local inflammatory response.

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