[Age and whole blood viscoelasticity. A risk factor study]

Area of Science:

• Biophysics
• Hematology
• Rheology

Context:

• Understanding blood's viscoelastic properties is crucial for diagnosing and managing various health conditions.
• Age and lifestyle factors like oral contraceptive use are known to influence physiological parameters.

Purpose:

• This study aimed to investigate the influence of aging and oral contraceptive use on the viscoelastic properties of whole blood (VEWB).
• The research also examined the relationship between VEWB and factors such as gender and smoking.

Summary:

• Viscoelasticity of whole blood and plasma were measured in 84 healthy adults across different shear rates.
• Univariate analysis revealed age increases whole blood elasticity at low shear rates and erythrocyte shear resistance, particularly in males.
• Multiple regression confirmed age and oral contraceptive use significantly relate to whole blood elasticity and erythrocyte shear resistance.

Impact:

• Findings highlight that age and oral contraceptive use are significant determinants of blood rheology.
• This research provides valuable insights into age-related changes and medication effects on blood flow dynamics.
• The results can inform clinical assessments and therapeutic strategies related to blood viscoelasticity.