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Related Concept Videos

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Clathrin Coated Vesicles

Clathrin-coated vesicles use endocytosis to transport receptors and lysosomal hydrolases from the Golgi to the lysosome in the late secretory pathway. Clathrin-mediated endocytosis was the first described endocytic process, and Clathrin-coated vesicles remain one of the most well-studied transport vesicles. The molecular machinery that generates clathrin-coated vesicles comprises over 50 proteins that precisely coordinate vesicle formation. Cell surface receptors concentrated in indented sites...
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Related Experiment Video

Updated: Jun 22, 2026

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins
11:30

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins

Published on: August 31, 2019

Capsosomes: subcompartmentalizing polyelectrolyte capsules using liposomes.

Brigitte Städler1, Rona Chandrawati, Kenneth Goldie

  • 1Centre for Nanoscience and Nanotechnology, Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia.

Langmuir : the ACS Journal of Surfaces and Colloids
|June 10, 2009
PubMed
Summary

Researchers developed capsosomes, novel polyelectrolyte capsules containing liposomes. This particle engineering advances artificial cell development for targeted biomedical applications.

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Related Experiment Videos

Last Updated: Jun 22, 2026

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins
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Assembly and Characterization of Polyelectrolyte Complex Micelles
08:44

Assembly and Characterization of Polyelectrolyte Complex Micelles

Published on: March 2, 2020

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Cellular Engineering

Background:

  • Next-generation therapeutics require multifunctional particle carriers mimicking cellular functions.
  • Key features include semipermeable shells for environmental communication and subcompartments for reactions.

Purpose of the Study:

  • To report the formation of capsosomes, a new class of polyelectrolyte capsules with liposomes as cargo.
  • To investigate the assembly and stability of these capsosomes for potential biomedical applications.

Main Methods:

  • Layer-by-layer assembly of polyelectrolytes (poly(styrene sulfonate) and poly(allylamine hydrochloride)) and liposomes (1,2-dioleoyl-sn-glycero-3-phosphocholine).
  • Characterization using quartz crystal microbalance with dissipation monitoring on planar substrates and silica particles.
  • Template removal to yield stable capsosomes.

Main Results:

  • Successful formation of capsosomes, polyelectrolyte capsules containing structurally intact liposomes.
  • Characterization confirmed multilayer film assembly of polyelectrolytes and liposomes.
  • Stable capsosomes with one or two layers of liposomes were obtained after template removal.

Conclusions:

  • Capsosomes represent a novel platform combining liposome and polyelectrolyte capsule advantages.
  • This technology is promising for creating artificial cells or organelles.
  • Potential applications in biomedicine requiring confined reaction environments.