Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Methods of Documentation VI: Case Management Model

Methods of Documentation VI: Case Management Model

The case management model is a multidisciplinary approach that involves healthcare professionals from diverse disciplines, such as physicians, nurses, therapists, social workers, and pharmacists, working collaboratively to address the various needs of patients. Each healthcare professional brings unique expertise and perspectives, contributing to a more comprehensive understanding of the patient's condition and tailoring treatment plans accordingly.
For example, a patient with a chronic illness...

Pharmacokinetic–Pharmacodynamic Relationship: Problems

Pharmacokinetic–Pharmacodynamic Relationship: Problems

The empirical approach to drug therapy optimization relies on correlating pharmacological response with administered dosage. Such an approach can be costly, time-consuming, and often yields poor correlation due to variables like formulation factors and drug elimination characteristics. A more precise approach correlates response with plasma drug concentration or the amount of drug in the body, rather than dosage. This is achieved through pharmacokinetic-pharmacodynamic (PK/PD) modeling, which...

Pharmaceutical Poisoning: Potential Scenarios

Pharmaceutical Poisoning: Potential Scenarios

Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...

Nursing Clinical Information System

Nursing Clinical Information System

Nursing Clinical Information System (NCIS)
A Nursing Clinical Information System (NCIS) is a specialized type of healthcare information system tailored to meet the unique needs of nursing practice. It incorporates the principles of nursing informatics to streamline information management and improve the quality of care delivery.
Critical attributes of NCIS include:

Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions

Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions

PK–PD modeling has significantly influenced FDA regulatory decisions, particularly drug approval, dosage optimization, and labeling. These models integrate pharmacokinetics (PK) and pharmacodynamics (PD) to predict drug behavior and effects, aiding in optimizing dosing regimens and enhancing the probability of clinical trial success.One notable example is Nesiritide (Natrecor®), a recombinant human brain natriuretic peptide for treating acute decompensated congestive heart failure (CHF).

Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems

Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems

Bioavailability is a critical pharmacological concept that measures the extent and rate at which an active drug ingredient or therapeutic moiety enters the systemic circulation, remaining unchanged. It's a pivotal factor in determining a drug's efficacy and safety.The Biopharmaceutics Classification System (BCS) plays an essential role in drug development by categorizing drugs into four classes based on their solubility and permeability. This classification aids in understanding drug absorption...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Plasma and intrapulmonary pharmacokinetics of ceftibuten and ledaborbactam in healthy male and female adults.

Antimicrobial agents and chemotherapy·2026

Same author

Pharmacokinetic and Pharmacodynamic Principles and Concepts Remain Relevant in the Era of Artificial Intelligence and Machine Learning.

Pharmacotherapy·2026

Same author

Pivmecillinam for Treatment of Uncomplicated Urinary Tract Infection: New Efficacy Analysis.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2025

Same author

Plasma and intrapulmonary pharmacokinetics of cefepime and taniborbactam in healthy adult participants.

Antimicrobial agents and chemotherapy·2025

Same author

Intrapulmonary pharmacokinetics of SPR719 following oral administration of SPR720 to healthy volunteers.

Antimicrobial agents and chemotherapy·2024

Same author

Lessons Are Still Being Learned about Intrapulmonary Antibiotic Concentrations.

American journal of respiratory and critical care medicine·2024

Search research articles

Related Experiment Video

Updated: Jun 22, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

Collaborative strategies for improving clinical resource utilization: how pharmacists can make a difference.

Keith A Rodvold¹

¹University of Illinois, Chicago, IL 60612, USA. kar@uic.edu

Journal of Managed Care Pharmacy : JMCP

|June 10, 2009

Summary

Ventilator-associated pneumonia (VAP) significantly increases hospital costs due to prolonged stays. Early, appropriate antibiotic treatment and prevention programs are key to reducing VAP

More Related Videos

Workflow and Framework for Collecting and Implementing Point-of-Care Ultrasound Data in the Management of Heart Failure Patients

Workflow and Framework for Collecting and Implementing Point-of-Care Ultrasound Data in the Management of Heart Failure Patients

Published on: July 12, 2024

Related Experiment Videos

Last Updated: Jun 22, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

Workflow and Framework for Collecting and Implementing Point-of-Care Ultrasound Data in the Management of Heart Failure Patients

Workflow and Framework for Collecting and Implementing Point-of-Care Ultrasound Data in the Management of Heart Failure Patients

Published on: July 12, 2024

Area of Science:

Critical care medicine
Health economics
Infectious diseases

Background:

Ventilator-associated pneumonia (VAP) imposes considerable financial burdens on hospitals.
Effective VAP prevention and management are crucial for resource optimization.

Purpose of the Study:

To review the economic impact of VAP.
To outline strategies for enhancing resource efficiency without compromising patient outcomes.

Main Methods:

Literature review on VAP costs and management.
Analysis of economic data and clinical outcomes related to VAP.

Main Results:

Prolonged hospital length of stay (LOS) is the primary driver of VAP costs.
Appropriate initial antimicrobial therapy, including combination therapy for resistant pathogens, improves outcomes.
VAP prevention programs, supported by multidisciplinary teams, enhance resource utilization.

Conclusions:

Optimizing antimicrobial therapy and implementing VAP prevention are vital.
A proactive, multidisciplinary approach is essential for reducing VAP incidence and associated costs.