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Preparation of Zinc Oxide Nanoparticles and the Evaluation of their Antibacterial Effects
Published on: September 27, 2024
Preparation, physicochemical characterization and biological evaluation of cefodizime metal ion complexes
Sayed H Auda1, Yahya Mrestani, Dietrich H Nies
1Institutes of Pharmacy, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.
Objectives:
Cefodizime is a broad spectrum cephalosporin belonging to the third generation agents. In this study, attention has been paid to the preparation, physicochemical characterization and biological evaluation of new Cu2+, Zn2+, Fe3+, Co2+ and Al3+ complexes of cefodizime.
Methods:
The stoichiometrics and the mode of bonding of the complexes were deduced from their elemental and metal analysis, electrical conductivity measurements, UV-vis, infrared and Raman spectroscopic investigations. Study of the stoichiometry of these complexes referred to the formation of 1 : 1 ratios of metal to ligand. Antimicrobial activity of the complexes was determined using two strains of Gram-positive (Bacillus subtilis and Proteus vulgaris) and two strains of Gram-negative (Escherichia coli W3110 and Pseudomonas putida) bacteria. The minimal inhibitory concentration was determined as the lowest concentration inhibiting bacterial growth on solid Luria Bertani medium.
Key Findings:
The spectra gave evidence as to the position of binding. In addition, the aqueous solubility of cefodizime was strongly reduced by complexation.
Conclusions:
The antibacterial activity of cefodizime was not affected by complexation with Al3+ but it was reduced by complexation with the other tested metal ions against the bacteria under study.
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