Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
Drugs in...
Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
Bioavailability Enhancement: Drug Solubility Enhancement01:16

Bioavailability Enhancement: Drug Solubility Enhancement

Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
Routes of Drug Administration: Enteral01:18

Routes of Drug Administration: Enteral

Medications can be administered through the enteral route using liquids, capsules, or tablets.
Enteral administration involves drug administration via the mouth in two ways: orally or sublingually.
Unlike sublingually drugs, drugs that are taken orally pass through the gastrointestinal (GI) tract and get metabolized by the liver. Once metabolized, the drug is absorbed into the systemic circulation, reaching different body parts via the bloodstream. However, while passing through the stomach,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High-throughput identification of bacterial β-glucuronidase inhibitors using machine learning.

Gut microbes·2026
Same author

Microbubbles manufactured using a tissue homogeniser: DoE-guided optimisation for a narrower size distribution and higher yield.

International journal of pharmaceutics·2026
Same author

Accurate low-temperature direct granule extrusion 3D printing of personalised paediatric minitablets.

International journal of pharmaceutics·2026
Same author

Cellulose nanocrystal stabilised Pickering emulgels for sustained colonic delivery of budesonide.

Colloids and surfaces. B, Biointerfaces·2026
Same author

Artificial intelligence-enabled personalisation of oral drug delivery: From data-driven design to on-demand manufacturing.

Advanced drug delivery reviews·2026
Same author

A multi-strain probiotic modulates gut microbiome composition, intestinal barrier integrity and inflammation in a multi-compartmental in vitro gut model of decompensated advanced chronic liver disease.

International journal of pharmaceutics·2026

Related Experiment Video

Updated: Jun 22, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
07:32

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

Drug distribution in enteric microparticles.

Suchada Nilkumhang1, Mohamed A Alhnan, Emma L McConnell

  • 1Department of Pharmaceutics, The School of Pharmacy, University of London, 29/39 Brunswick Square, London, WC1N 1AX, UK.

International Journal of Pharmaceutics
|June 10, 2009
PubMed
Summary
This summary is machine-generated.

Drug distribution in enteric microparticles depends on molecule partitioning. Molecules favoring the internal phase show better encapsulation and even distribution, enabling effective enteric drug delivery.

More Related Videos

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles
09:56

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles

Published on: August 2, 2016

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
09:57

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

Published on: December 23, 2016

Related Experiment Videos

Last Updated: Jun 22, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
07:32

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles
09:56

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles

Published on: August 2, 2016

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
09:57

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

Published on: December 23, 2016

Area of Science:

  • Pharmaceutical Technology
  • Drug Delivery Systems
  • Materials Science

Background:

  • Enteric microparticles are crucial for targeted drug delivery.
  • Understanding drug distribution within microparticles is key to optimizing release profiles.
  • Eudragit L is a pH-responsive polymer suitable for enteric formulations.

Purpose of the Study:

  • To investigate the distribution of fluorescent molecules (riboflavin, dipyridamole, acridine orange) within enteric microparticles.
  • To correlate physicochemical properties of drugs with their encapsulation and distribution.
  • To assess the impact of drug distribution on pH-responsive drug release.

Main Methods:

  • Microparticle preparation using emulsion solvent evaporation with Eudragit L.
  • Dispersion of drugs and polymer in ethanol, emulsified in liquid paraffin.
  • Confocal laser scanning microscopy (CLSM) for visualizing drug distribution.
  • Evaluation of encapsulation efficiency and in vitro drug release at acidic pH.

Main Results:

  • Riboflavin, partitioning into ethanol, showed efficient encapsulation and even distribution.
  • Dipyridamole and acridine orange, partitioning into liquid paraffin, localized to the surface with lower encapsulation.
  • All microparticles exhibited limited drug release in acidic conditions (<10%).
  • Drug distribution had minimal impact on the observed pH-responsive release.

Conclusions:

  • Physicochemical properties, specifically partition coefficient, significantly influence drug distribution in Eudragit L microparticles.
  • Microparticle technology demonstrates potential for broad applicability in enteric drug delivery.
  • Further research can optimize formulations based on drug partitioning behavior for enhanced efficacy.