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Human serum induces streptococcal c5a peptidase expression.

Ute Gleich-Theurer1, Simone Aymanns, Gregor Haas

  • 1Insitute of Medical Microbiology and Hygiene, University of Ulm, D-89081 Ulm, Germany.

Infection and Immunity
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Human serum specifically induces Streptococcus agalactiae's C5a peptidase (scpB) gene, highlighting its role in human infections. This contrasts with bovine strains lacking scpB induction, suggesting host adaptation.

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Area of Science:

  • Microbiology
  • Molecular Biology
  • Pathogen Adaptation

Background:

  • Streptococcus agalactiae is a significant human and animal pathogen.
  • Virulence factors, like C5a peptidase (scpB) and Lmb, are often linked to mobile genetic elements and host-modulated expression.
  • The scpB and Lmb genes are located on a composite transposon absent in many bovine isolates.

Purpose of the Study:

  • To investigate the role of scpB and Lmb genes in Streptococcus agalactiae's adaptation to human hosts.
  • To determine the influence of human and bovine serum on the promoter activity of scpB and lmb.

Main Methods:

  • Fluorescence-activated cell sorter analysis to measure reporter gene activity for scpB and lmb promoter.
  • Culturing S. agalactiae in varying concentrations of human and fetal calf serum.
  • Reverse transcription-PCR to confirm differential gene induction.

Main Results:

  • Human serum dose-dependently induced reporter gene activity for scpB, but not lmb.
  • Fetal calf serum did not alter reporter gene activity.
  • A bovine S. agalactiae strain showed no induction of scpB by either human or bovine serum.

Conclusions:

  • The C5a peptidase (scpB) gene in S. agalactiae is specifically induced by human serum.
  • This human-specific induction suggests scpB is a crucial virulence factor for human infections.
  • The absence of scpB induction in bovine strains supports its role in host adaptation.