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Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism
11:04

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism

Published on: September 1, 2014

Independent determinants of the Tei index in hypertensive patients with preserved left ventricular systolic function

Hisashi Masugata1, Shoichi Senda, Fuminori Goda

  • 1Department of Integrated Medicine, Kagawa University, Kagawa, Japan.

International Heart Journal
|June 10, 2009
PubMed

Insights

The Tei index, reflecting left ventricular function, may offer prognostic value in hypertensive patients. It appears linked to early diastolic dysfunction and heart remodeling, alongside the E/A ratio.

Area of Science:

  • Cardiology
  • Echocardiography
  • Hypertension Research

Background:

  • The Tei index assesses left ventricular (LV) systolic and diastolic function and has prognostic value in heart disease.
  • Transmitral E/A ratio also shows prognostic value in hypertensive patients.
  • The Tei index's utility in hypertensive patients without overt heart disease is understudied.

Purpose of the Study:

  • To compare the Tei index between hypertensive and normotensive patients.
  • To identify independent determinants of the Tei index in hypertensive patients with preserved LV systolic function.

Main Methods:

  • Doppler echocardiography was used to measure LV structural and functional parameters.
  • 319 patients with cardiovascular risk factors (hypertension, diabetes) and preserved LV systolic function (ejection fraction ≥ 55%) were studied.
  • Patients were divided into normotensive (n=100) and hypertensive (n=219) groups.

Main Results:

  • The Tei index correlated most closely with transmitral E velocity (r = -0.311, P < 0.001) in hypertensive patients.
  • Stepwise regression identified E velocity (β = -0.315, P < 0.001) and relative wall thickness (β = 0.262, P < 0.001) as independent determinants of the Tei index.
  • Hypertensive patients showed differences in Tei index compared to normotensive patients (implied, not explicitly stated as a result).

Conclusions:

  • The Tei index in hypertensive patients with preserved LV systolic function may primarily reflect early diastolic dysfunction and LV concentric remodeling.
  • The Tei index, along with the E/A ratio, may hold prognostic significance in hypertensive individuals.

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