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Tumor marker determinations.

L Lukinac1, Z Kusić, M Franceschi

  • 1Department of Nuclear Medicine & Oncology, University Hospital Sestre milosrdnice, Zagreb.

Acta Medica Iugoslavica
|January 1, 1991
PubMed
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This study evaluated tumor markers for various cancers. CA 19-9 for gastrointestinal cancer and CA 15-3 for breast cancer showed potential in detecting relapse or metastases.

Area of Science:

  • Oncology
  • Clinical Chemistry

Background:

  • Tumor markers are crucial for cancer management, aiding in diagnosis, prognosis, and monitoring treatment efficacy.
  • The utility of specific tumor markers varies across different cancer types, necessitating individualized evaluation.

Purpose of the Study:

  • To assess the diagnostic and monitoring value of several tumor markers in patients with differentiated thyroid cancer, gastrointestinal cancer, breast cancer, and melanoma.
  • To determine the correlation between tumor marker levels and disease status (relapse or metastases) in these patient cohorts.

Main Methods:

  • Serum samples from 478 patients with malignant tumors were analyzed for various tumor markers.
  • Thyroglobulin (Tg) was measured in thyroid cancer patients.
  • CA 19-9, TPA, and IAP were measured in gastrointestinal cancer patients.

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  • CA 15-3 was measured in breast cancer patients.
  • TPA and IAP were assessed for melanoma monitoring.

    • Main Results:

    • Undetectable thyroglobulin (Tg) levels were observed in most differentiated thyroid cancer patients without relapse or metastases.
    • CA 19-9 demonstrated the highest discrepancy in detecting relapse or metastases in gastrointestinal cancer patients.
    • Increased CA 15-3 values were significantly more frequent in breast cancer patients with relapse or metastases compared to those without.
    • The combination of TPA and IAP showed no value in monitoring melanoma patients.

    Conclusions:

    • Tumor markers like CA 19-9 and CA 15-3 show promise for detecting relapse and metastases in gastrointestinal and breast cancers, respectively.
    • Thyroglobulin (Tg) levels are useful in monitoring differentiated thyroid cancer.
    • The combination of TPA and IAP is not recommended for melanoma monitoring.