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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

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Updated: Jun 22, 2026

Therapeutic Massage for Psychological Well-being in Geriatric Oncology
03:59

Therapeutic Massage for Psychological Well-being in Geriatric Oncology

Published on: May 22, 2026

Combined modality therapy in the elderly population.

Lilie L Lin1, Stephen M Hahn

  • 1Department of Radiation Oncology, University of Pennsylvania, 3400 Spruce Street, 2 Donner Building, Philadelphia, PA 19104, USA. lin@xrt.upenn.edu

Current Treatment Options in Oncology
|June 10, 2009
PubMed
Summary
This summary is machine-generated.

Cancer treatment for older adults is improving survival, but combined therapies increase toxicity. Comprehensive geriatric assessments are vital for selecting fit elderly patients for treatment, ensuring better outcomes.

Related Experiment Videos

Last Updated: Jun 22, 2026

Therapeutic Massage for Psychological Well-being in Geriatric Oncology
03:59

Therapeutic Massage for Psychological Well-being in Geriatric Oncology

Published on: May 22, 2026

Area of Science:

  • Geriatric Oncology
  • Cancer Treatment
  • Clinical Trials

Background:

  • Rising incidence of cancer in older patients.
  • Combined modality therapy improves survival in various cancers but increases toxicity.
  • Elderly patients are often excluded from clinical trials, leading to a lack of evidence-based treatment guidelines.

Purpose of the Study:

  • To advocate for the inclusion of elderly patients in cancer treatment decisions.
  • To emphasize the importance of comprehensive geriatric assessments for treatment selection.
  • To encourage the development of age-inclusive clinical trials.

Main Methods:

  • Review of current treatment paradigms for elderly cancer patients.
  • Highlighting the need for individualized treatment plans.
  • Promoting the use of comprehensive geriatric assessments.

Main Results:

  • Age should not be a sole criterion for excluding elderly patients from combined modality therapy.
  • Careful patient selection, considering life expectancy and comorbidities, is crucial.
  • Comprehensive geriatric assessments improve functional status during therapy.

Conclusions:

  • Fit elderly patients can be candidates for combined modality therapy.
  • Attention to hydration, nutrition, and early intervention is necessary due to increased vulnerability.
  • Clinical trials should expand eligibility to include elderly patients and develop elderly-specific trials.