Related Experiment Video
Updated: Jun 22, 2026

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
Published on: April 17, 2013
Acute myeloid leukemia with infiltration of thyroid gland complicating Hashimoto's thyroiditis
Shoko Nakayama1, Taiji Yokote, Kichinosuke Kobayashi
1Department of Internal Medicine (I), Osaka Medical College, Takatsuki City, Osaka, 569-0801, Japan. in1304@poh.osaka-med.ac.jp
Abstract:
We describe a case of acute myeloid leukemia with infiltration of thyroid gland complicating Hashimoto's thyroiditis. In Hashimoto's thyroiditis, the leukocyte function-associated antigen-1 (LFA-1)/intercellular vascular cell adhesion molecule-1 (ICAM-1) and very late antigen-4 (VLA-4)/vascular cell adhesion molecule-1 (VCAM-1) pathways in T lymphocytes and the vascular endothelium both play a role in the initiation and enhancement of lymphocyte recruitment to the thyroid glands during an autoimmune attack. The leukemic blast cells were positive for VLA-4 and negative for LFA-1 by immunohistochemistry. The presence of VLA-4 in blast cells might play a key role in the migration of blast cells to the thyroid glands.
Related Concept Videos
Graves' Disease I: Introduction
Hyperthyroidism I: Introduction
Graves Disease II: Pathophysiology
Hyperthyroidism II: Pathophysiology
Goiter
Synthesis and Regulation of Thyroid Hormones
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The iodine is then...
