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Updated: Jun 22, 2026

Measuring Global Cellular Matrix Metalloproteinase and Metabolic Activity in 3D Hydrogels
Published on: January 22, 2019
[The role of changes of matrix metalloproteinase in cardiovascular diseases]
Abstract:
The review summarizes information about changes of extracellular matrix (ECM) in cardiovascular diseases. Special attention is paid to different groups of extra cellular matrix proteins (collagen I and III type, fibronectine) in the development of cardiac fibrosis in chronic heart failure. The role of matrix metalloproteinases in degradation of components of ECM is analyzed. Interrelationship between matrix metalloproteinases and their tissue inhibitors in fibrosis and cardiac structural chances is analyzed.
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