Related Experiment Video
Updated: Jun 22, 2026

Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention
Published on: October 16, 2013
[Adverse effect of local anaesthetics]
H S Brand1, A H te Veldhuis, J A Baart
1Afdeling Mondziekten en Kaakchirurgie van het Vrije Universiteit medisch centrum (VUmc)/Academisch Centrum Tandheelkunde Amsterdam (ACTA). hs.brand@vumc.nl
Abstract:
Local anaesthetics are frequently administered preceding oral treatment. Since little is known about the incidence of adverse effects after administration of local anaesthetics, a prospective study involving a group of 219 patients was performed. The most frequently observed complications were insufficient anaesthesia (17%) and positive blood aspiration (3%). Pain during administration, paralysis, blanching, haematoma, and vasovagal collapse occurred each in less than 1% of the patients. The results suggested that administration of local anaesthetics involves a limited risk of adverse events and that the adverse events are usually minor and transient.
Related Concept Videos
Local Anesthetics: Adverse Effects
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
Local Anesthetics: Pharmacokinetics
Local Anesthetics: Differential Sensitivity of Nerve Fibers
Local Anesthetics: Chemistry and Structure-Activity Relationship
Local Anesthetics: Mechanism of Action
Local anesthetics are amphiphilic molecules consisting of a hydrophobic aromatic part linked to a hydrophilic group by an ester or amide linkage. They are weak bases and are usually available as salts, which increases their solubility and stability. Once administered, LAs exist in the body either...
Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia
