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Related Concept Videos

Human Genetics01:28

Human Genetics

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Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
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Dementia01:30

Dementia

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Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
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Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

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Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
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Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
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Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

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Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
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Genetic Lingo01:11

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Overview
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Related Experiment Video

Updated: Feb 17, 2026

Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration
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Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration

Published on: January 9, 2020

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[Genetic basis for dementia].

Ryozo Kuwano1, Norihiro Takei, Akinori Miyashita

  • 1Department of Molecular Genetics, Center for Bioresources, Brain Research Institute, Niigata University.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|June 11, 2009
PubMed
Summary
This summary is machine-generated.

Genetic research aims to find risk factor loci for complex disorders like dementia. Genome-wide association studies may reveal common genetic insights into dementia etiology.

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A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
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Last Updated: Feb 17, 2026

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Area of Science:

  • Neuroscience
  • Genetics
  • Gerontology

Context:

  • Dementia is a prevalent neurodegenerative disorder in the elderly.
  • Common types include Alzheimer disease, dementia with Lewy bodies, and frontotemporal lobar degeneration.
  • These conditions share overlapping symptoms and neuropathological features, complicating diagnosis.

Purpose:

  • To identify genetic risk factor loci for complex disorders.
  • To understand the molecular mechanisms underlying disease development.
  • To gain insights into the common etiology of dementia through genetic research.

Summary:

  • Genetic research seeks to identify risk factor loci for complex disorders and understand their molecular mechanisms.
  • Dementia, a common neurodegenerative disorder in the elderly, encompasses Alzheimer disease, dementia with Lewy bodies, and frontotemporal lobar degeneration.
  • Genome-wide association studies (GWAS) offer a potential avenue for uncovering genetic factors common to various forms of dementia.

Impact:

  • Potential to improve diagnostic accuracy for complex dementias.
  • May lead to the development of targeted therapies for dementia.
  • Advances understanding of the genetic underpinnings of neurodegeneration.