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Updated: Jun 22, 2026
11:15
Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
Published on: September 20, 2016
[Advances in genome analysis of solid tumors]
1Division of Molecular Pathology, Institute of Medical Science, The University of Tokyo.
Nihon Rinsho. Japanese Journal of Clinical Medicine
|June 11, 2009
Summary
The post-genomic era offers new cancer prevention and treatment strategies. Genome-based analyses combined with molecular therapies enable personalized cancer medicine.
Area of Science:
- Genomics and Bioinformatics
- Oncology
- Molecular Biology
Context:
- The post-genomic era has introduced novel strategies for cancer prevention and treatment.
- Genome-wide association studies (GWAS) identify single nucleotide polymorphisms (SNPs) associated with cancer susceptibility.
- Molecular-targeting drugs are advancing cancer therapy, exemplified by EGFR tyrosine kinase inhibitors.
Purpose:
- To review advancements in genome-based cancer prevention and treatment.
- To highlight the role of genetic biomarkers in predicting treatment response.
- To discuss the potential of personalized medicine in oncology.
Summary:
- Genome-wide association studies have identified SNPs for predicting susceptibility to breast and gastric cancers.
- EGFR mutations predict gefitinib response in lung adenocarcinoma.
- MammaPrint analysis predicts breast cancer response to Herceptin.
- Molecular targeting therapy combined with genome-based analyses offers personalized cancer medicine.
Impact:
- Advances in personalized medicine for cancer treatment.
- Improved prediction of individual patient response to targeted therapies.
- Enhanced strategies for cancer prevention through genetic risk assessment.
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