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Updated: Jun 22, 2026

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
Published on: July 20, 2022
Left atrial volume as a predictor of heart function
G Valocik1, P Mitro, L Druzbacka
1IIIrd Department of Internal Medicine, University Hospital, Louis Pasteur's Hospital, Faculty of Medicine, Safarikiensis University, Kosice, Slovakia. valocik@central.medic.upjs.sk
Insights
This study found that increased left atrial volume is strongly associated with left ventricular systolic and diastolic dysfunction. Left ventricular mass was the best predictor of enlarged left atrial volume.
Area of Science:
- Cardiology
- Echocardiography
- Cardiac Function
Background:
- Left atrial volume is linked to cardiovascular risk factors.
- Understanding the relationship between left atrial volume and left ventricular function is crucial for cardiovascular health assessment.
Purpose of the Study:
- To investigate the association between left atrial volume and left ventricular systolic and diastolic functions.
- To determine the predictive value of left ventricular mass on left atrial volume.
Main Methods:
- Retrospective analysis of transthoracic echocardiographic data from 268 patients.
- Correlation of key echocardiographic variables of systolic and diastolic function with indexed left atrial volume.
Main Results:
- Left atrial volume significantly increased with deteriorating diastolic function (impaired relaxation, pseudonormalized, restrictive).
- Significant differences in left atrial volume were observed between normal systolic function and systolic dysfunction.
- Left ventricular mass was identified as the strongest predictor of enlarged left atrial volume.
Conclusions:
- A strong association exists between left atrial volume and left ventricular systolic and diastolic dysfunction.
- Left atrial volume serves as a significant indicator of impaired cardiac function.
- Left ventricular mass is a key determinant of increased left atrial volume.
Objectives:
This study was designed to identify an association between left atrial volume and systolic and diastolic functions of the left ventricle.
Background:
Several studies have shown a relationship between the left atrial volume and different cardiovascular risk factors.
Methods:
Transthoracic echocardiographic results of 268 patients (136 women and 132 men, mean age 60.2+/-17.3 years) were studied retrospectively. Key echocardiographic variables of systolic and diastolic function were related to the left atrial volume and its indexed value.
Results:
The mean indexed left atrial volume in a subgroup of patients with normal echocardiography, was 25.3+/-6.7 ml/m2. Left atrial volume significantly (p<0.0001) increased in deteriorating diastolic function (impaired relaxation, pseudonormalized pattern, and restrictive physiology): 33.6+/-11.6, 48.7+/-21.8 and 84.5+/-60.5 ml/m2, respectively. There were also significant (p=0.0001) differences in cases with normal systolic function (EF>50 %) and systolic dysfunction (EF<50%): 37.9+/-24.1 vs 54.9+/-34.7 ml/m2. There were no significant differences in the left atrial volumes (33.1+/-10.9 ml/m2 and 38.3+/-15.4 ml/m2, p=0.13) in patients with normal systolic function and impaired relaxation compared to patients with systolic dysfunction. However, in both cases these values were different from those with normal echocardiography (p<0.0001). In multiple regression analysis the best predictor of enlarged left atrial volume was the left ventricular mass.
Conclusion:
We found a strong association between left atrial volume and left ventricular systolic and diastolic dysfunction. The strongest association appeared between increasing left atrial volume and left ventricular mass (Tab. 2, Fig. 4, Ref. 26). Full Text (Free, PDF) www.bmj.sk.
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