Immunofluorescent study of polyps in nose and paranasal cavities

Aim of this research was an immunofluorescent study and to measure immunoglobulins status of the polyps in the nose and paranasal cavities.

Polyps of the nose and the paranasal cavities are very often guised, and their frequency is growing with increasing chemicals and allergens. These factors interfere important research on polyps. Developments in allergology and immunology help in the detection of etiopathogenetical mechanisms of polyposis development, like the disturbance in mucus immunity.

Clinical material was collected from 100 hospitalized patients at the Department for otorinolarynology, Clinical center of Nis. All patients had transnasal ethmoidectomy and polypectomy. In 19 patients trepanation of maxillary sinus (Coldwell Luc's) was made. Materials were examined by immunofluorescense.

IgA immunofluorescency was negative in all examined parameters when examined under a ultraviolet luminescent with immunofluorescent microscope. IgM immunofluorescency was also negative in all examined parameters while IgG immunofluorescency was positive, but with different degree of intensity. The C3b fraction complement showed positive immunofluorescency in 80% with standard intensity ++++ in all examined preparations.

Study of adenoids approved disarrangement in immune elimination in all examined preparations has shown very little immunity including the "second line of defense". High percent positive C3b complement fractions, with alongside emphasis on IgG response, instigate existing humoral reaction. The epithelium is very liable to many recurrent infections, wherewith beginning end of one permanent etiopathogenetical circle IgG-C3b-mastocits-eozinophils-lgA. Profusely blocked immune-eliminations and large production of mucous can cause some nasal diseases (Tab. 2, Fig. 2, Ref. 15). Full Text (Free, PDF) www.bmj.sk.