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High Throughput SiRNA Screening for Chloropicrin and Hydrogen Fluoride-Induced Cornea Epithelial Cell Injury

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Unintentional endosulfan poisoning.

Salim Satar¹, Ahmet Sebe, Nezihat Rana Alpay

¹Cukurova University, School of Medicine, Department of Emergency Medicine, Balcali-Adana, Turkey.

Bratislavske Lekarske Listy

|June 11, 2009

Summary

Endosulfan poisoning can cause severe seizures and metabolic disturbances. Prompt symptomatic treatment, including thiopental sodium and hemodialysis, led to full recovery in all reported cases of organochloride insecticide intoxication.

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Area of Science:

Toxicology
Emergency Medicine
Environmental Health

Background:

Endosulfan, an organochloride insecticide, is widely used for pest control.
Endosulfan intoxication is associated with severe health consequences, including fatalities.
Prompt medical intervention is crucial for managing endosulfan poisoning.

Purpose of the Study:

To report a case series of endosulfan poisoning.
To describe the clinical courses and treatment outcomes.
To highlight effective management strategies for severe endosulfan intoxication.

Main Methods:

Case series of patients admitted with endosulfan poisoning.
Clinical observation and documentation of symptoms and treatment.
Review of treatment interventions, including anticonvulsants and hemodialysis.

Main Results:

Two patients presented with status epilepticus, successfully managed with thiopental sodium.
One patient required hemodialysis in addition to supportive care.
All patients experienced complete recovery and were discharged in good health.

Conclusions:

Endosulfan poisoning presents with severe neurological and metabolic disturbances.
Symptomatic and supportive treatment, including specific interventions like thiopental sodium and hemodialysis, is effective.
Early and appropriate medical management ensures favorable outcomes in endosulfan poisoning cases.