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Updated: Jun 22, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

Annular leucocytoclastic vasculitis.

H Imanishi1, D Tsuruta, M Ishii

  • 1Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan.

Clinical and Experimental Dermatology
|June 11, 2009
PubMed
Summary
This summary is machine-generated.

Annular leucocytoclastic vasculitis (ALV) presents as rare, target-like skin lesions. This study reports two cases, demonstrating ALV is a morphological variant of small-vessel vasculitis, effectively treated with oral prednisolone.

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Published on: August 13, 2015

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Last Updated: Jun 22, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
06:35

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Published on: February 8, 2019

Intravital Microscopy of Leukocyte-endothelial and Platelet-leukocyte Interactions in Mesenterial Veins in Mice
05:12

Intravital Microscopy of Leukocyte-endothelial and Platelet-leukocyte Interactions in Mesenterial Veins in Mice

Published on: August 13, 2015

Area of Science:

  • Dermatology
  • Rheumatology
  • Pathology

Background:

  • Leucocytoclastic vasculitis (LV) involves necrotizing inflammation of small blood vessels, primarily with neutrophils.
  • Skin manifestations of LV are typically polymorphous, with annular variants being uncommon.

Observation:

  • Two cases of annular leucocytoclastic vasculitis (ALV) are presented in elderly male patients.
  • Both patients exhibited pruritic, erythematous to purpuric targetoid lesions on various body parts.
  • Histopathological examination confirmed leucocytoclastic vasculitis throughout the dermis in both individuals.

Findings:

  • Morphologically, the cases were categorized as annular LV (ALV).
  • Clinically, both cases were classified as small-vessel vasculitis.
  • Rapid symptom resolution was observed in both patients following treatment with oral prednisolone.

Implications:

  • Annular leucocytoclastic vasculitis is not a distinct disease entity but represents a spectrum of small-vessel vasculitides.
  • The findings support ALV as a morphological presentation of underlying small-vessel vasculitis.
  • Early diagnosis and treatment with corticosteroids can effectively manage ALV symptoms.