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Haemophilia A (factor VIII deficiency) in a litter of Weimaraners
M D Dunning1, G F Averis, H Pattinson
1Department of Veterinary Medicine, University ofCambridge, Madingley Road, Cambridge CB3 0ES, UK.
Abstract:
Inherited coagulopathies are reported in a number of dog breeds. However, to date, there is no report of Weimaraners suffering factor VIII deficiency (haemophilia A). We report the discovery of haemophilia A in both males from a single litter of Weimaraners. Haemophilia A in human beings often results from a de novo stochastic mutation. We found no evidence using currently available screening tests of haemophilia A in relatives as far back as three generations making a stochastic mutation possible in this litter.
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