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Related Experiment Video

Updated: Jun 22, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Pustular porokeratosis.

Daniel D Miller¹, Beth S Ruben

¹Departments of Dermatology, University of California - San Francisco, USA.

Journal of Cutaneous Pathology

|June 11, 2009

Summary

Disseminated superficial actinic porokeratosis (DSAP) can present with unusual pustules. This case highlights a rare variant, complicating diagnosis and underscoring the need for careful histopathologic examination in diagnosing porokeratosis.

Area of Science:

Dermatology
Histopathology
Clinical Case Reports

Background:

Disseminated superficial actinic porokeratosis (DSAP) is a common condition characterized by multiple small, scaly papules and plaques.
The typical histopathologic feature of porokeratosis is the cornoid lamella, a parakeratotic column of cells.
Pustular variants of skin conditions can present diagnostic challenges.

Observation:

A unique case of DSAP exhibited neutrophilic pustules within the cornoid lamellae.
Clinically, these corresponded to pustules observed along the characteristic elevated rim of the lesions.
Literature review revealed only one prior report linking pustules with porokeratosis.

Findings:

The histopathologic findings confirmed the presence of pustules within the cornoid lamellae in this DSAP case.

Related Experiment Videos

Last Updated: Jun 22, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

This represents a rare pustular variant of disseminated superficial actinic porokeratosis.

The co-occurrence of pustules and DSAP is exceptionally uncommon.

Implications:

This unusual presentation of DSAP can pose diagnostic difficulties for clinicians.
Recognition of this variant is crucial for accurate diagnosis and appropriate patient management.
Further research may elucidate the pathogenesis of pustule formation in porokeratosis.