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Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

Electrochemical sensor for multiplex biomarkers detection.

Fang Wei¹, Prabhudas Patel, Wei Liao

¹Department of Mechanical and Aerospace Engineering, University of California, Los Angeles, California, USA.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research

|June 11, 2009

Summary

This summary is machine-generated.

This study introduces a novel electrochemical sensor for detecting oral cancer by simultaneously measuring interleukin (IL)-8 mRNA and protein in saliva. This point-of-care diagnostic tool achieves high sensitivity and specificity, paving the way for early cancer detection.

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Area of Science:

Biomarker Discovery
Molecular Diagnostics
Point-of-Care Testing

Background:

Multiplexing assays for point-of-care molecular diagnostics remain a significant challenge.
Oral cancer diagnosis relies on detecting specific biomarkers, but simultaneous detection of multiple types is complex.

Purpose of the Study:

To develop an electrochemical (EC) sensor for oral cancer detection.
To achieve simultaneous detection of two salivary biomarkers: interleukin (IL)-8 mRNA and IL-8 protein.

Main Methods:

An electrochemical sensor was designed for the simultaneous detection of IL-8 mRNA and IL-8 protein in saliva.
The sensor's performance was evaluated using multiplexing mode on clinical saliva samples from oral cancer patients and healthy controls.

Main Results:

The EC sensor demonstrated limits of detection of 3.9 fM for IL-8 mRNA and 7.4 pg/mL for IL-8 protein.
The multiplex assay showed significant differences between cancer and control groups, achieving approximately 90% sensitivity and specificity.
Combined detection of IL-8 mRNA and protein yielded a better area under the curve (AUC) compared to single biomarker detection.

Conclusions:

This work presents the first concurrent multiplexing detection of salivary mRNA and protein biomarkers using a point-of-care EC sensor.
The developed sensor shows potential for early and accurate oral cancer diagnosis at the point-of-care.