Related Experiment Video
Updated: Jun 22, 2026
07:24
Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube (SWCNT)-delivered MALAT1 Antisense Oligos
Published on: December 13, 2018
Toward an effective targeted chemotherapy for multiple myeloma
Andrew G Polson1, Mark X Sliwkowski
1Genentech Inc, South San Francisco, California 94080, USA.
Summary
Antibody-drug conjugates (ADCs) show promise for multiple myeloma by targeting cancer cells. Further research is needed to understand the safety of using CD138-targeted ADCs in cancer therapy.
Area of Science:
- Oncology
- Immunotherapy
- Pharmacology
Background:
- Antibody-drug conjugates (ADCs) are designed to deliver cytotoxic drugs specifically to neoplastic cells, enhancing chemotherapy efficacy.
- Anti-CD138 ADCs have demonstrated significant preclinical effectiveness in treating multiple myeloma.
Discussion:
- The therapeutic potential of anti-CD138 ADCs in multiple myeloma is promising.
- However, the safety profile associated with targeting the CD138 antigen requires thorough investigation.
Key Insights:
- ADCs offer a targeted approach to chemotherapy, improving drug delivery to cancer cells.
- Preclinical studies support the efficacy of anti-CD138 ADCs against multiple myeloma.
Outlook:
- Further research is essential to evaluate the safety and tolerability of CD138-targeted therapies.
- Understanding the safety aspects will be crucial for the clinical translation of these novel cancer treatments.
Related Concept Videos
02:57Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
02:57Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
02:50Combination Therapies and Personalized Medicine
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
01:27Tumor Immunotherapy
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
02:56Treatment Resistant Cancers
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
02:56Treatment Resistent Cancers
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...