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Warfarin-induced intracerebral hemorrhage associated with microbleeds

Gha-Hyun Lee1, Sun U Kwon, Dong-Wha Kang

  • 1Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Journal of Clinical Neurology (Seoul, Korea)
|June 11, 2009
PubMed
Abstract

Insights

Microbleeds (MBs) may increase the risk of warfarin-induced intracerebral hemorrhage (ICH) in acute ischemic stroke patients. Further research is needed to confirm this association.

Area of Science:

  • Neurology
  • Radiology

Background:

  • Cerebral microbleeds (MBs) are potential biomarkers for microangiopathy.
  • MBs may predict spontaneous or thrombolysis-related intracerebral hemorrhage (ICH) in acute ischemic stroke.
  • The link between MBs and warfarin-induced ICH remains unclear.

Purpose of the Study:

  • To investigate the relationship between pre-existing microbleeds and the occurrence of warfarin-induced ICH.
  • To present case studies of patients experiencing ICH at MB sites after warfarin administration.

Main Methods:

  • Case report methodology.
  • Review of previous MRI scans to identify documented microbleeds.
  • Analysis of patient cases involving warfarin-induced ICH.

Main Results:

  • Two cases of warfarin-induced ICH were identified.
  • ICH occurred at the specific sites of previously documented MBs.

Conclusions:

  • The presence of MBs may elevate the risk of ICH in ischemic stroke patients using warfarin.
  • Larger cohort studies are necessary to validate the association between MBs and warfarin-induced ICH.
Keywords:
AnticoagulationIntracerebral hemorrhageMagnetic resonance imaging

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