Effects of cholinotropic and cytostatic drugs on the development of Arthus reaction
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Updated: Jun 22, 2026

Intracoronary Acetylcholine Provocation Testing for Assessment of Coronary Vasomotor Disorders
Published on: August 18, 2016
G I Nezhinskaya1, N S Sapronov, A L Vladykin
1S. V. Anichkov Department of Neuropharmacology, Institute of Experimental Medicine, the Russian Academy of Medical Sciences, St. Petersburg, Russia. sns@iem.spb.ru
Abstract:
Antimuscarinic effects of ipratropium bromide and atropine are associated with prevention of the development of Arthus reaction, while the cytostatic effects of cyclophosphamide and doxorubicin lead to involution of the thymus and spleen, suppression of antibody production, and aggravation of inflammation, which causes edema of the ankle joint (cyclophosphamide treatment). Apoptosis of tumor cell and inhibition of inflammation can be essential for chemotherapy of malignant and autoimmune diseases.
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