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Updated: Jun 22, 2026

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
Published on: March 11, 2014
Cutaneous human papillomavirus in head and neck squamous cell carcinomas
Katja Lindel1, Burkhard Helmke, Christian Simon
1Department of Radiation Oncology and Radiotherapy, University of Heidelberg, Heidelberg, Germany. Katja Lindel@med.uni-heidelberg.de
Abstract:
To evaluate the prevalence and meaning of cutaneous human papillomavirus (HPV) types in HNSCC 51 patients were analyzed for the prevalence of cutaneous as well as mucosal HPV. HPV DNA was demonstrated in 18 (35%) of 51 tumors. The majority of these HPV types belong to so-called cutaneous HPV types, whereas only HPV 6 and HPV 16 were from the mucosal HPV types. A possible role for cutaneous HPV types as co-factors in the oncogenesis of HNSCC remains to be elucidated and may be relevant for future strategies of cancer prevention.
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