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Related Experiment Video

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Improved Polymerase Chain Reaction-restriction Fragment Length Polymorphism Genotyping of Toxic Pufferfish by Liquid Chromatography/Mass Spectrometry

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Microchip technology in mass spectrometry.

Tiina Sikanen¹, Sami Franssila, Tiina J Kauppila

¹Faculty of Pharmacy, Division of Pharmaceutical Chemistry, University of Helsinki, Helsinki, Finland. tiina.sikanen@helsinki.fi

Mass Spectrometry Reviews

|June 11, 2009

Summary

Microfabrication enables miniaturized analytical devices for mass spectrometry (MS). This review covers microfabricated ion sources and mass analyzers, highlighting integrated systems for enhanced MS analysis.

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Area of Science:

Analytical Chemistry
Instrumental Analysis
Microfluidics

Background:

Microfabrication is increasingly applied to analytical devices.
Miniaturized instruments are entering the field of mass spectrometry (MS).
Integration of microfabricated components with MS is a growing area of interest.

Purpose of the Study:

To review recent advancements in microfabricated ion sources and mass analyzers for MS.
To focus on the development of fully microfabricated analytical systems.
To discuss microfabrication methods, materials, and their constraints.

Main Methods:

Review of microfabrication techniques for analytical devices.
Analysis of miniaturized ion sources (electrospray, atmospheric pressure chemical ionization, photoionization).
Examination of microfabricated mass analyzers and their integration with ionization sources.

Main Results:

Successful microfabrication of various ion sources and mass analyzers for MS.
Development of integrated systems combining microfluidics, pumps, detectors, and MS components.
Demonstration of microfabricated systems applied to MS analysis.

Conclusions:

Microfabrication offers significant potential for developing compact and efficient MS instruments.
Integration of microfabricated ion sources and mass analyzers with other microfluidic devices is key to fully microfabricated systems.
Continued research in microfabrication methods and materials will drive further innovation in analytical instrumentation.