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[Immunobiological properties of recombinant L peptide from the Pseudomonas aeruginosa outer membrane]

E V Gatypova, S A Zlygostev, A A Kaloshin

    Vestnik Rossiiskoi Akademii Meditsinskikh Nauk
    |June 12, 2009
    PubMed

    The gene encoding plasma membrane protein L (OprL) was cloned and expressed in E. coli. It was shown that the recombinant protein had immunogenic properties and protected laboratory animals from experimental P. aeruginosa infection. Rabbit hyperimmune sera raised against recombinant L protein possessed antimicrobial activity and prevented infection with P. aeruginosa.

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