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Abnormal Proliferation

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...

Abnormal Proliferation

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...

Disorders of Leukocytes

Disorders of Leukocytes

Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...

Disorders of the Male Reproductive System

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

Cellular Adaptation III: Hyperplasia

Cellular Adaptation III: Hyperplasia

Hyperplasia is an increase in the number of cells in a tissue or organ due to enhanced cell division. It is an adaptive, controlled response to stimuli such as injury, hormones, or stress, involving mitosis to produce genetically identical cells and support tissue repair and regeneration.Tissue CapacityCertain tissues, including the epidermis, intestinal epithelium, bone marrow, and fibroblasts, have a high potential for hyperplasia. Others, such as bone, cartilage, and smooth muscle, show...

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[Longchang granule upregulates the expression of bax in the prostatic hyperplastic tissues of rats].

Zhonghua nan ke xue = National journal of andrology·2009

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[Progress in studies of glutathione S-transferase P1 and prostate cancer].

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[Effect of soluble granule of Shengjing on the apoptosis in spermatogenic cells of rats caused by varicocele].

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Related Experiment Video

Updated: Jun 22, 2026

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing

Published on: August 14, 2019

[B-cell lymphoma/leukemia-2 and benign prostatic hyperplasia].

Min-Dao Zhang¹, Yong-Ning Zhao, Li-Wen An

¹Graduate of Grade 2006, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, China. zhangmindao1981@163.com

Zhonghua Nan Ke Xue = National Journal of Andrology

|June 12, 2009

Summary

The Bcl-2 gene, crucial for cell apoptosis, is increasingly linked to benign prostatic hyperplasia (BPH). Understanding Bcl-2

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Surgical Treatment for Benign Prostatic Hyperplasia: Holmium Laser Enucleation of the Prostate (HoLEP).

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Last Updated: Jun 22, 2026

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing

Published on: August 14, 2019

Enucleation of the Prostate for the Treatment of Benign Prostatic Hyperplasia Using a 980 nm Diode Laser

Enucleation of the Prostate for the Treatment of Benign Prostatic Hyperplasia Using a 980 nm Diode Laser

Published on: May 5, 2020

Surgical Treatment for Benign Prostatic Hyperplasia: Holmium Laser Enucleation of the Prostate (HoLEP).

Surgical Treatment for Benign Prostatic Hyperplasia: Holmium Laser Enucleation of the Prostate (HoLEP).

Published on: March 6, 2018

Area of Science:

Molecular Biology
Cell Biology
Oncology

Context:

The B-cell lymphoma/leukemia-2 (Bcl-2) gene is a key regulator of apoptosis.
Apoptosis, or programmed cell death, is vital for maintaining cellular homeostasis.
Benign prostatic hyperplasia (BPH) is a common condition with incompletely understood mechanisms.

Purpose:

To explore the role of the Bcl-2 gene in the development and progression of benign prostatic hyperplasia (BPH).
To investigate the correlation between Bcl-2 gene expression and BPH pathogenesis.
To highlight the significance of apoptosis in BPH.

Summary:

The Bcl-2 gene, a critical apoptosis regulator, influences cell survival by counteracting programmed cell death.
Evidence suggests a strong association between the Bcl-2 gene and the development of benign prostatic hyperplasia (BPH).
Bcl-2's role in prolonging cell life contributes to the cellular imbalance seen in BPH.

Impact:

Provides insights into the molecular mechanisms underlying benign prostatic hyperplasia (BPH).
Highlights the potential of targeting the Bcl-2 pathway for BPH treatment strategies.
Emphasizes the importance of apoptosis regulation in prostate health.