Related Experiment Video
Updated: Jun 22, 2026
08:03
Intracavernosal Pressure Recording to Evaluate Erectile Function in Rodents
Published on: June 6, 2018
[NADPH oxidase and male erectile dysfunction].
1Department of Urology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Zhonghua Nan Ke Xue = National Journal of Andrology
|June 12, 2009
Summary
Oxidative stress from NADPH oxidase overproduction of reactive oxygen species in the penis is a key cause of erectile dysfunction (ED). Targeting NADPH oxidase may offer new treatments for ED.
Area of Science:
- Urology
- Biochemistry
- Pathophysiology
Background:
- Erectile dysfunction (ED) is a prevalent condition in men.
- Oxidative stress is a significant contributing factor to ED pathogenesis.
- NADPH oxidase (NOX) enzymes are implicated in cellular oxidative stress.
Purpose of the Study:
- To review the composition, homologues, activation, and physiological roles of NADPH oxidase.
- To elucidate the specific role of NADPH oxidase in the development of erectile dysfunction.
- To explore the therapeutic potential of targeting NADPH oxidase for ED treatment.
Main Methods:
- Literature review focusing on NADPH oxidase.
- Analysis of studies investigating oxidative stress mechanisms in erectile dysfunction.
- Synthesis of information on NADPH oxidase function and its link to penile pathophysiology.
Main Results:
- NADPH oxidase is expressed in the penis and contributes to oxidative stress.
- Overproduction of reactive oxygen species by NADPH oxidase in the penis leads to erectile dysfunction.
- Understanding NADPH oxidase pathways is crucial for ED research.
Conclusions:
- NADPH oxidase plays a critical role in mediating oxidative stress-induced erectile dysfunction.
- Inhibition or modulation of NADPH oxidase activity presents a potential therapeutic strategy for managing ED.
- Further research into NADPH oxidase inhibitors is warranted for ED treatment development.
Related Concept Videos
01:17Male Sexual Response: Erection & Ejaculation
Sexual stimulation can take various forms, such as physical touch and visual or auditory cues. When this happens, the parasympathetic reflex in the sacral portion of the spinal cord is activated. This reflex stimulates the release of nitric oxide (NO), which then dilates the arterioles in the penis, increasing blood flow to the erectile tissues - the corpora cavernosa and corpus spongiosum.
The blood filling the erectile tissues compresses the veins, which helps to prevent blood from leaving...
The blood filling the erectile tissues compresses the veins, which helps to prevent blood from leaving...
01:28Nitric Oxide Signaling Pathway
Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure to...
01:20Disorders of the Male Reproductive System
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...
01:28Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors
Phosphodiesterase 5 (PDE5) inhibitors are potent enzymes that function to hydrolyze cyclic nucleotides to their corresponding 5' monophosphates. Their unique biochemical properties have been applied in treating Pulmonary Arterial Hypertension (PAH).
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
01:23Antihypertensive Drugs: Vasodilators
Vasodilators, primarily affecting the smooth muscles within arterial and venous walls, are commonly used for hypertension treatment. Medications such as minoxidil and hydralazine primarily target arteries and arterioles, while sodium nitroprusside acts on arterioles and venules. Minoxidil, functioning as a prodrug, is metabolized by hepatic sulfotransferase into its active form, minoxidil sulfate, after oral administration. This metabolite binds to the sulfonylurea receptor (SUR) component of...
01:17Oxidation of Phenols to Quinones
In the presence of oxidizing agents, phenols are oxidized to quinones. Quinones can be easily reduced back to phenols using mild reducing agents. The electron-donating hydroxyl group enhances the reactivity of the aromatic ring, enabling oxidation of the ring even in the absence of an α hydrogen.
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox property is crucial in...
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox property is crucial in...