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Safety of a preservative system containing 1,2-hexanediol and caprylyl glycol
Stanley B Levy1, Anthony M Dulichan, Michael Helman
1Revlon Research Center, Edison, New Jersey, USA. slevy@mindspring.com
Cutaneous and Ocular Toxicology
|June 12, 2009
Abstract:
To study the potential for delayed Type IV dermal sensitivity of a new preservative system containing 1,2-hexanediol and caprylyl glycol, 200-subject repeat insult patch tests were performed with a 15% mixture of 1,2-hexanediol and caprylyl glycol (equal parts of the 2 ingredients) in carbomer gel and a cosmetic formulation at an actual use concentration. No delayed Type IV hypersensitivity reactions were observed.
