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Related Experiment Video

Updated: Jun 22, 2026

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

High-throughput formulation screening system for self-microemulsifying drug delivery.

Kenichi Sakai¹, Hiroyuki Maeda, Takayuki Yoshimori

¹Formulation Technology Research Department, Chugai Pharmaceutical Co., Ltd., Kita-Ku, Tokyo, Japan. sakaikni@chugai-pharm.co.jp

Drug Development and Industrial Pharmacy

|June 12, 2009

Summary

A new high-throughput formulation screening (HTFS) system rapidly identifies optimal self-microemulsifying drug delivery system (SMEDDS) formulations and surfactant combinations with minimal resources.

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Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes

Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes

Published on: March 3, 2020

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Last Updated: Jun 22, 2026

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes

Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes

Published on: March 3, 2020

Area of Science:

Pharmaceutical Sciences
Drug Delivery Systems
Formulation Development

Background:

Self-microemulsifying drug delivery systems (SMEDDS) enhance oral bioavailability of poorly soluble drugs.
Efficient screening methods are crucial for optimizing SMEDDS formulations.
Traditional screening methods can be time-consuming and resource-intensive.

Purpose of the Study:

To develop a high-throughput formulation screening (HTFS) system for SMEDDS.
To enable rapid and efficient selection of optimal SMEDDS formulations.
To identify the most suitable hydrophilic surfactant (HS)/lipophilic surfactant (LS) combinations for SMEDDS.

Main Methods:

Utilized a robotic liquid dispenser for formulation preparation.
Employed a turbidity assay for screening emulsion particle size and phase stability.
Developed a SMEDDS-HTFS system for rapid evaluation.

Main Results:

Formulations were prepared rapidly (40 min/96 formulations).
Screenings for particle size and stability were highly efficient (1 min/96 formulations).
The system identified optimal SMEDDS formulations and HS/LS combinations with minimal manpower and compound usage.

Conclusions:

The developed SMEDDS-HTFS system allows for rapid and efficient selection of SMEDDS formulations.
This system facilitates the identification of optimal hydrophilic and lipophilic surfactant combinations.
The HTFS approach significantly reduces time, manpower, and compound consumption in SMEDDS development.