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Related Experiment Video

Updated: Jun 22, 2026

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

Inside the wire: aggression and functional interhemispheric connectivity in the human brain.

Dennis Hofman¹, Dennis J L G Schutter

¹Experimental Psychology, Helmholtz Institute, Utrecht University, Utrecht, The Netherlands. d.hofman@uu.nl

Psychophysiology

|June 12, 2009

Summary

Aggressive personality traits are linked to brain connectivity differences. Specifically, higher left-to-right transcallosal inhibition (TCI) correlates with increased aggression and attention to angry faces.

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Area of Science:

Neuroscience
Psychology
Cognitive Science

Background:

Aggressive personality is hypothesized to stem from frontal cortical asymmetry.
Understanding the neural basis of aggression and attention is crucial.

Purpose of the Study:

To investigate the relationship between aggressive personality style and functional interhemispheric connectivity.
To explore the neural mechanisms underlying aggression and attentional bias.

Main Methods:

Utilized transcranial magnetic stimulation (TMS) to measure transcallosal inhibition (TCI) in 20 healthy volunteers.
Administered the Buss-Perry Aggression Questionnaire (AQ) and a selective attention task.
Correlated TCI measures with AQ scores and attentional bias for angry faces.

Main Results:

Higher left-to-right TCI significantly correlated with higher AQ scores.
Increased left-to-right TCI and decreased right-to-left TCI were associated with a stronger attentional bias for angry faces.
This study provides the first biological evidence linking frontal asymmetry to human aggression.

Conclusions:

Aggressive personality style is positively correlated with functional interhemispheric connectivity.
Selective attention to angry faces is also linked to altered interhemispheric connectivity patterns.
Findings suggest a neural mechanism for aggression related to frontal lobe functional asymmetry.