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Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery
09:12

Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery

Published on: March 27, 2018

Morbidity and mortality following coronary artery bypass graft surgery in patients with cirrhosis: a population-based

Abdel Aziz M Shaheen1, Gilaad G Kaplan, James N Hubbard

  • 1Liver Unit, Department of Medicine, Division of Gastroenterology, University of Calgary, Calgary, AB, Canada.

Liver International : Official Journal of the International Association for the Study of the Liver
|June 12, 2009
PubMed

Insights

Patients with cirrhosis undergoing coronary artery bypass graft (CABG) surgery face significantly higher risks of mortality and complications. This population-based study highlights the increased morbidity and mortality associated with CABG in cirrhotic patients.

Area of Science:

  • Cardiovascular Surgery
  • Hepatology
  • Transplantation

Background:

  • The surgical risks for patients with cirrhosis undergoing coronary artery bypass graft (CABG) surgery are not well-established.
  • This study aimed to define the outcomes of CABG in patients with cirrhosis from a population-based perspective.

Purpose of the Study:

  • To evaluate the outcomes of coronary artery bypass graft (CABG) surgery in patients diagnosed with cirrhosis.
  • To assess the impact of cirrhosis on mortality, complications, length of stay, and healthcare charges following CABG.

Main Methods:

  • Analysis of the 1998-2004 Nationwide In-patient Sample database to identify patients undergoing CABG.
  • Logistic regression models were employed to assess the effect of cirrhosis on key outcomes.

Main Results:

  • Cirrhotic patients (0.2% of total) had a significantly increased risk of mortality (17% vs. 3%) and complications (43% vs. 28%) after CABG.
  • Cirrhosis was associated with longer hospital stays and higher charges (P<0.0001).
  • Predictors of mortality included age, female gender, ascites, and congestive heart failure; hospital volume and off-pump CABG did not impact mortality.

Conclusions:

  • Patients with cirrhosis experience a substantially elevated risk of morbidity and mortality post-CABG surgery.
  • Further research is needed to improve risk stratification for this high-risk group.
Abstract

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