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Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Electroconvulsive Therapy01:30

Electroconvulsive Therapy

Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early years,...

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Related Experiment Video

Updated: Jun 22, 2026

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus
09:46

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus

Published on: March 8, 2015

An update on brain stimulation for epilepsy.

Christopher Todd Anderson1, Kathryn Davis, Gordon Baltuch

  • 1Department of Neurology, Penn Epilepsy Center, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA. cand@mail.med.upenn.edu

Current Neurology and Neuroscience Reports
|June 12, 2009
PubMed
Summary
This summary is machine-generated.

Brain stimulation is showing renewed promise for epilepsy treatment, with recent large trials offering hope for patients with difficult-to-treat seizures. Advances in technology are driving these improvements in neurological care.

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A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
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A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

Published on: November 13, 2016

Related Experiment Videos

Last Updated: Jun 22, 2026

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus
09:46

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus

Published on: March 8, 2015

Direct-current Stimulation and Multi-electrode Array Recording of Seizure-like Activity in Mice Brain Slice Preparation
09:39

Direct-current Stimulation and Multi-electrode Array Recording of Seizure-like Activity in Mice Brain Slice Preparation

Published on: June 7, 2016

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
08:23

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

Published on: November 13, 2016

Area of Science:

  • Neurology
  • Neurosurgery
  • Biomedical Engineering

Background:

  • Brain stimulation for epilepsy has a long history but suffered from inconsistent results and limited adoption.
  • Advances in deep brain stimulation for movement disorders and technological progress have revitalized interest in epilepsy applications.

Purpose of the Study:

  • To summarize the latest findings from recent large-scale, randomized, blinded, multicenter trials on brain stimulation for epilepsy.
  • To highlight the potential of emerging brain stimulation technologies for managing refractory epilepsy.

Main Methods:

  • Review of recent large-scale, randomized, blinded, multicenter clinical trials.
  • Synthesis of up-to-date findings on brain stimulation efficacy and safety in epilepsy.

Main Results:

  • Recent trials demonstrate improved outcomes and growing interest in brain stimulation for epilepsy.
  • Technological advancements are enhancing the precision and effectiveness of these interventions.

Conclusions:

  • Brain stimulation is a rapidly evolving field with significant potential to improve outcomes for patients with refractory epilepsy.
  • Continued research and technological innovation are expected to further enhance the utility of these therapies.