Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
Whole Body Regeneration01:33

Whole Body Regeneration

Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential; even...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In vivo programming of adult pericytes aids axon regeneration by providing cellular bridges for SCI repair.

Molecular therapy : the journal of the American Society of Gene Therapy·2025
Same author

Collagen I is a critical organizer of scarring and CNS regeneration failure.

bioRxiv : the preprint server for biology·2024
Same author

Recovery of Forearm and Fine Digit Function After Chronic Spinal Cord Injury by Simultaneous Blockade of Inhibitory Matrix Chondroitin Sulfate Proteoglycan Production and the Receptor PTPσ.

Journal of neurotrauma·2023
Same author

Inhibition of CSPG receptor PTPσ promotes migration of newly born neuroblasts, axonal sprouting, and recovery from stroke.

Cell reports·2022
Same author

An adult-stage transcriptional program for survival of serotonergic connectivity.

Cell reports·2022
Same author

Histomorphometry in Peripheral Nerve Regeneration: Comparison of Different Axon Counting Methods.

The Journal of surgical research·2021
Same journal

Hunting ecology predicts eye arrangements in the modular visual system of spiders.

Current biology : CB·2026
Same journal

Sub-second fluctuations between top-down and bottom-up modes distinguish diverse human brain states.

Current biology : CB·2026
Same journal

Queen bees offload pesticide burden to eggs when social buffering is overwhelmed.

Current biology : CB·2026
Same journal

Pitch selectivity in ferret auditory cortex.

Current biology : CB·2026
Same journal

A cell size-dependent competition between geometry and polarity governs nuclear and spindle positioning in early embryos.

Current biology : CB·2026
Same journal

Trophic cascades drive sustainability in the agricultural heritage rice-fish coculture system.

Current biology : CB·2026
See all related articles

Related Experiment Video

Updated: Jun 22, 2026

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling
10:45

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

Published on: May 31, 2017

CNS regeneration: only on one condition.

Jerry Silver1

  • 1Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA. jxs10@po.cwru.edu

Current Biology : CB
|June 12, 2009
PubMed
Summary
This summary is machine-generated.

Mammalian central nervous system (CNS) regeneration is limited. However, conditioning dorsal root ganglion neurons enables central axon regeneration, and reversing lesion sequence can also promote rapid CNS regeneration under specific circumstances.

More Related Videos

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration
08:52

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration

Published on: January 10, 2018

Investigating Functional Regeneration in Organotypic Spinal Cord Co-cultures Grown on Multi-electrode Arrays
08:25

Investigating Functional Regeneration in Organotypic Spinal Cord Co-cultures Grown on Multi-electrode Arrays

Published on: September 23, 2015

Related Experiment Videos

Last Updated: Jun 22, 2026

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling
10:45

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

Published on: May 31, 2017

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration
08:52

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration

Published on: January 10, 2018

Investigating Functional Regeneration in Organotypic Spinal Cord Co-cultures Grown on Multi-electrode Arrays
08:25

Investigating Functional Regeneration in Organotypic Spinal Cord Co-cultures Grown on Multi-electrode Arrays

Published on: September 23, 2015

Area of Science:

  • Neuroscience
  • Cell Biology
  • Regenerative Medicine

Background:

  • The mammalian central nervous system (CNS) typically exhibits limited regenerative capacity after injury.
  • Peripheral nerve injury conditioning can prime dorsal root ganglion (DRG) neurons for subsequent CNS axon regeneration.
  • Understanding the factors that promote CNS regeneration is crucial for developing therapeutic strategies.

Discussion:

  • This study investigates the impact of reversing the order of peripheral and central axon lesions on DRG neuron regeneration.
  • It reveals that under specific conditions, rapid regeneration through a CNS lesion can occur even when the peripheral axon is lesioned second.
  • This challenges the conventional understanding of conditioning in promoting CNS repair.

Key Insights:

  • The sequence of axonal injury significantly influences the regenerative potential of DRG neurons within the CNS.
  • Specific cellular or molecular cues present when the CNS lesion occurs second can overcome the usual inhibitory environment.
  • This finding opens new avenues for exploring therapeutic interventions for spinal cord injury.

Outlook:

  • Further research is needed to elucidate the precise molecular mechanisms driving this reversed-sequence regeneration.
  • Identifying these mechanisms could lead to novel strategies for enhancing CNS repair and functional recovery.
  • Exploring the role of glial cells and the inflammatory response in this phenomenon is warranted.