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Updated: Jun 22, 2026
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Published on: March 6, 2018
Postradiotherapy 2-year prostate-specific antigen nadir as a predictor of long-term prostate cancer mortality
Michael J Zelefsky1, Weiji Shi, Yoshiya Yamada
1Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. zelefskm@mskcc.org
Purpose:
To report the influence of posttreatment prostate-specific antigen (PSA) nadir response at 2 years after external beam radiotherapy (RT) on distant metastases (DM) and cause-specific mortality (CSM).
Methods And Materials:
Eight hundred forty-four patients with localized prostate cancer were treated with conformal RT. The median duration of follow-up was 9.1 years. A fixed landmark time point at 2 years was used to assess the influence of nadir PSA value as a time-dependent variable on long-term outcomes.
Results:
Multivariate analysis demonstrated that nadir PSA
Conclusions:
Nadir PSA values of
