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Matrix metalloproteinase-2 gene variants and abdominal aortic aneurysm

L Smallwood1, N Warrington, R Allcock

  • 1School of Surgery, University of Western Australia, Fremantle Hospital, Fremantle, WA 6959, Australia.

European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery
|June 12, 2009
PubMed
Abstract

Insights

Genetic variations in the matrix metalloproteinase-2 gene (MMP2) were studied for their link to abdominal aortic aneurysm (AAA). The findings indicate that these specific MMP2 variants are not risk factors for developing or expanding AAA.

Area of Science:

  • Genetics
  • Cardiovascular Science
  • Molecular Biology

Background:

  • Abdominal aortic aneurysm (AAA) is a serious vascular condition.
  • Matrix metalloproteinase-2 (MMP2) plays a role in extracellular matrix remodeling, potentially influencing AAA development.
  • Understanding genetic predispositions to AAA is crucial for risk stratification.

Purpose of the Study:

  • To examine the association between two specific matrix metalloproteinase-2 gene (MMP2) polymorphisms (-1360C>T and +649C>T) and the incidence of abdominal aortic aneurysm (AAA).
  • To investigate the relationship between these MMP2 variants and the progression (expansion) of existing AAAs.

Main Methods:

  • A case-control study design was employed, recruiting participants from an AAA screening trial.
  • Genotyping for MMP2 -1360C>T and +649C>T single nucleotide polymorphisms (SNPs) was performed in men with AAA (n=678) and controls (n=659).
  • Multivariate analyses were used to assess the association with AAA presence and expansion (n=638), with adjustments for multiple testing.

Main Results:

  • Multivariate analyses revealed no statistically significant association between the MMP2 -1360C>T polymorphism and AAA presence or expansion.
  • Similarly, the MMP2 +649C>T polymorphism showed no significant association with either the incidence or expansion of abdominal aortic aneurysms.
  • Adjustments for multiple testing confirmed the lack of a detectable link between these SNPs and AAA outcomes.

Conclusions:

  • The investigated MMP2 gene variants, specifically -1360C>T and +649C>T, do not appear to be significant risk factors for abdominal aortic aneurysm.
  • These findings suggest that common MMP2 polymorphisms may not play a major role in the genetic susceptibility or progression of AAA in the studied population.

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