Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hydroxychloroquine retinopathy.

A Weiner1, M A Sandberg, A R Gaudio

  • 1Berman-Gund Laboratory, Massachusetts Eye and Ear Infirmary, Boston 02114.

American Journal of Ophthalmology
|November 15, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Retraction Note: Gene therapy with a promoter targeting both rods and cones rescues retinal degeneration caused by AIPL1 mutations.

Gene therapy·2024
Same author

Corticosteroid signaling at the brain-immune interface impedes coping with severe psychological stress.

Science advances·2019
Same author

Photoreceptor rescue by an abbreviated human RPGR gene in a murine model of X-linked retinitis pigmentosa.

Gene therapy·2015
Same author

Inhibition imposed by developing flowers on further flower-bud initiation in Chamelaucium uncinatum Schau.

Planta·2013
Same author

Detection and identification of banned processed animal protein in feedingstuffs by microscopic and PCR methods.

Polish journal of veterinary sciences·2012
Same author

Gene therapy with a promoter targeting both rods and cones rescues retinal degeneration caused by AIPL1 mutations.

Gene therapy·2009

Hydroxychloroquine retinopathy can affect peripheral vision and the macula in patients with systemic lupus erythematosus. Retinal function may stabilize after discontinuing hydroxychloroquine treatment.

Area of Science:

  • Ophthalmology
  • Rheumatology
  • Pharmacology

Background:

  • Hydroxychloroquine is commonly prescribed for autoimmune conditions like systemic lupus erythematosus.
  • Ocular toxicity, including hydroxychloroquine retinopathy, is a known potential side effect.

Observation:

  • Two patients with systemic lupus erythematosus developed ocular findings after long-term hydroxychloroquine treatment.
  • Symptoms ranged from visual disturbances to being asymptomatic, despite similar visual acuities.
  • Both patients exhibited pericentral scotomata and abnormal electroretinogram responses.

Findings:

  • Ophthalmoscopy and fluorescein angiography revealed bull's-eye maculopathy and perifoveal depigmentation.
  • Electroretinography showed reduced and delayed full-field responses and abnormal foveal cone function.

Related Experiment Videos

  • Retinal function remained stable 18-24 months post-treatment cessation.

    • Implications:

    • Hydroxychloroquine retinopathy can manifest as both peripheral retinopathy and maculopathy.
    • Early detection and monitoring are crucial for patients on long-term hydroxychloroquine therapy.
    • Cessation of hydroxychloroquine may lead to stable retinal function, highlighting the importance of treatment review.