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Unilateral diplophthalmos.

F H Stefani1, N Hausmann, O E Lund

  • 1Augenklinik University München, Germany.

American Journal of Ophthalmology
|November 15, 1991
PubMed
Summary
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This study reports a rare case of unilateral diplophthalmos, a condition where a child developed two eyes in one orbit, alongside other craniofacial abnormalities. The findings suggest a developmental anomaly originating from a single optic vesicle.

Area of Science:

  • Ophthalmology
  • Developmental Biology
  • Teratology

Background:

  • Congenital ocular anomalies can result from disruptions during early embryonic development.
  • Diplophthalmos, or duplication of the eye, is an extremely rare malformation.

Observation:

  • A full-term infant presented with unilateral diplophthalmos, ipsilateral temporoparietal porencephaly, supernumerary teeth, and a cervical cyst.
  • A near-normal left globe was found attached to a smaller, supernumerary eye in the same orbit.
  • The supernumerary eye exhibited rudimentary structures including an avascular retina and optic disk.

Findings:

  • Histopathological examination post-enucleation revealed a secondary globe arising from the primary optic vesicle.
  • The anomaly is hypothesized to result from damage during lens induction by the primary optic vesicle contacting the ectoderm.

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  • The Chernobyl disaster's potential teratogenic effects were considered but deemed unlikely for this specific case.

    • Implications:

    • This case provides insight into the complex mechanisms of early eye development and potential points of failure.
    • Understanding such anomalies aids in diagnosing and managing rare congenital malformations.
    • Further research is needed to elucidate the precise etiological factors in complex craniofacial and ocular duplications.