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Updated: Jun 22, 2026

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat
Published on: February 27, 2014
Nuclear pregnane X receptor single nucleotide polymorphism (-25385C/T) is not associated with inflammatory bowel
Martin Lacher1, Roland Kappler, Sebastian Schroepf
1Department of Pediatric Surgery, Dr von Haunersches Kinderspital, Ludwig-Maximilians-University of Munich, Lindwurmstr, Munich, Germany. martin.lacher@lmu.de
Objective:
Studies in adults characterized the role of the pregnane X receptor (PXR) in the pathophysiology of inflammatory bowel disease (IBD) with conflicting results; pediatric studies are still lacking.
Patients And Methods:
Genotyping for the -25385C/T polymorphism of the PXR gene in 187 white children with IBD and 185 controls. Determination of colonic PXR expression in selected patients with IBD.
Results:
Minor allele frequency was seen in 35.6% patients with IBD and 40.5% controls (P = 0.174), although no significant differences were seen between the genotypes (P = 0.366). PXR was underexpressed in colonic tissue of 7 out of 11 Crohn disease and in 4 out of 5 patients with ulcerative colitis.
Conclusions:
We could not confirm an association of the -25385C/T polymorphism in pediatric patients with IBD.
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