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A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis
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Both extrauterine and intrauterine growth restriction impair renal function in children born very preterm

Justine Bacchetta1, Jérôme Harambat, Laurence Dubourg

  • 1Centre de Référence des Maladies Rénales Rares, Service de Néphrologie et Rhumatologie Pédiatriques, Hôpital Femme Mère Enfant, Bron Cedex, France. justine.bacchetta@chu-lyon.fr

Kidney International
|June 12, 2009
PubMed

Insights

Premature infants with intrauterine or extrauterine growth restriction show reduced glomerular filtration rates in childhood. Extrauterine growth restriction is a novel risk factor for long-term kidney impairment in these children.

Area of Science:

  • Pediatrics
  • Nephrology
  • Neonatology

Background:

  • Premature birth is associated with various health complications.
  • Growth restriction in premature infants can impact long-term organ function.
  • Renal function in childhood following prematurity requires further investigation.

Purpose of the Study:

  • To identify alterations in renal function during childhood in children born prematurely.
  • To assess the impact of intrauterine and extrauterine growth restriction on renal parameters.
  • To determine if extrauterine growth restriction is a risk factor for renal impairment.

Main Methods:

  • Prospective cohort study of 143 premature infants (birth weight < 1000 g and/or < 30 weeks gestation).
  • Renal evaluation at a mean follow-up of 7.6 years for 50 included children.
  • Glomerular filtration rate measured by inulin clearance; comparison between growth-restricted and normotrophic groups.

Main Results:

  • Growth-restricted children (intrauterine and extrauterine) exhibited significantly lower glomerular filtration rates compared to normotrophic children.
  • All measured glomerular filtration rates remained within the normal age-specific range.
  • Extrauterine growth-restricted children had lower initial protein-energy intake and a significant association with postnatal corticosteroid exposure.

Conclusions:

  • Children born prematurely with intrauterine or extrauterine growth retardation are at risk for decreased glomerular filtration rates in childhood.
  • Extrauterine growth restriction is identified as a new risk factor for long-term renal impairment in premature children.
  • Early nutritional intake and postnatal exposures may influence renal outcomes in premature infants.

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