Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Genome-wide Association Studies-GWAS

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...

Human Genetics

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...

Incomplete Dominance

Incomplete Dominance

Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.

Pharmacogenomics: Identification of New Drug Targets

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...

The JAK-STAT Signaling Pathway

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...

Principles of Pharmacogenetics: Types of Genetic Variants

Principles of Pharmacogenetics: Types of Genetic Variants

The human genome is over 99.9% identical between individuals, yet genetic differences exist at millions of bases. The human genome contains approximately 3 million variant positions per individual, many of which are heterozygous, contributing to genetic diversity and individual traits. Genetic variations include single-nucleotide polymorphisms (SNPs), insertions, deletions, and copy number variations (CNVs).SNPs, the most common variation, involve single-base changes in DNA. These can be...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Association between progression of knee osteoarthritis pathology and gait changes over two years: Data from the IMI-APPROACH cohort.

Osteoarthritis imaging·2026

Same author

Impact of quantified knee positioning on the measurement of minimal joint space width using statistical shape models: A cross-sectional and longitudinal analysis in the IMI-APPROACH.

Osteoarthritis imaging·2026

Same author

Vasoactive intestinal peptide advances chondrogenesis and modulates pathogenic mediators in human osteoarthritis.

Journal of molecular medicine (Berlin, Germany)·2026

Same author

Abatacept versus hydroxychloroquine for prevention of rheumatoid arthritis in individuals with palindromic rheumatism: a randomized open-label trial.

Nature medicine·2026

Same author

Progression of bone and joint space deformity in patients with mild knee osteoarthritis: Data from the IMI-APPROACH cohort.

Osteoarthritis and cartilage open·2026

Same author

Redox-Related Genetic and Biological Ageing Signals in Rapid Pain Progression of Knee Osteoarthritis: A Hypothesis-Generating Analysis in the Osteoarthritis Initiative.

Antioxidants (Basel, Switzerland)·2026

Search research articles

Related Experiment Video

Updated: Jun 22, 2026

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness

Published on: March 18, 2022

Genetics in osteoarthritis.

Mercedes Fernández-Moreno¹, Ignacio Rego, Vanessa Carreira-Garcia

¹Osteoarticular and Aging Research Lab, Genomics Unit. Biomedical Research Center, INIBIC-CH Universitario A Coruña, A Coruña, Spain.

Current Genomics

|June 12, 2009

Summary

Osteoarthritis involves complex genetic factors contributing to cartilage deterioration. Understanding these genetic influences is crucial for future diagnosis and treatment strategies.

Keywords:

Osteoarthritis chondrocyte cytokines.genetics

Related Experiment Videos

Last Updated: Jun 22, 2026

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness

Published on: March 18, 2022

Area of Science:

* Genetics and Molecular Biology
* Rheumatology and Orthopedics

Background:

* Osteoarthritis (OA) is a degenerative joint disease characterized by cartilage deterioration.
* Its complex etiology involves multifactorial interactions, with a significant genetic component recognized since the 1950s.

Purpose of the Study:

* To explore the genetic underpinnings of osteoarthritis (OA).
* To highlight the role of multiple genes in OA susceptibility and pathogenesis.

Main Methods:

* Review of existing literature on the genetic basis of osteoarthritis.
* Analysis of candidate gene identification studies.

Main Results:

* OA's genetic basis does not follow simple Mendelian inheritance patterns.
* Numerous candidate genes have been identified, indicating a polygenic contribution to OA.
* Altered gene expression levels are observed in OA development.

Conclusions:

* The precise genetic mechanisms of OA remain largely unknown.
* Genetic factors play a substantial role in OA, influencing future diagnostic and therapeutic approaches.