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Published on: May 18, 2020
Disposable bioreactors: maturation into pharmaceutical glycoprotein manufacturing
1ProBioGen AG, Goethestrasse 54, Berlin, Germany. rene.brecht@probiogen.de
Advances in Biochemical Engineering/Biotechnology
|June 12, 2009
Summary
Disposable bioreactors offer flexible, cost-effective solutions for biopharmaceutical production, enabling tailored processes and faster development times for biologic drugs. This technology supports GMP-compliant manufacturing up to market supply.
Area of Science:
- Biopharmaceutical Manufacturing
- Biotechnology
- Chemical Engineering
Background:
- Modern biopharmaceutical development emphasizes structure-activity relationships, requiring production processes tailored to product needs.
- High production costs and long development times are major challenges in the biologics industry.
Purpose of the Study:
- To summarize the development of disposable bioreactor technology over the past decade.
- To compare different disposable bioreactor technologies and identify future trends.
Main Methods:
- Review and comparison of various disposable bioreactor technologies available in the market.
- Analysis of their suitability for different applications, including GMP-compliant production.
Main Results:
- A significant increase in the number and types of disposable bioreactors over the last 10 years.
- Disposable bag systems now support bioreactor volumes up to 2,000 L.
- Technologies are available for various purposes, including GMP-compliant therapeutic drug production and market supply.
Conclusions:
- Disposable bioreactors provide flexibility for tailored processes and can help reduce production costs and development time.
- The technology supports diverse operational modes within the same facility.
- Future trends indicate continued innovation and broader adoption in biopharmaceutical manufacturing.
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