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Renal hemodynamic changes during serial seizures in rats.
R M Zweifler1, E M Slaven, L L Rihn
1Department of Physiology, Tulane University School of Medicine, New Orleans, Louisiana 70112.
The American Journal of Physiology
|November 1, 1991
Summary
During experimental seizures, initial drops in renal blood flow (RBF) were blocked by renal denervation or adrenalectomy. Later seizures showed reduced blood pressure and RBF responses to norepinephrine.
Area of Science:
- Nephrology
- Neurology
- Cardiovascular Physiology
Background:
- Status epilepticus can cause significant physiological changes.
- Hemodynamic alterations during seizures are not fully understood.
Purpose of the Study:
- To investigate changes in renal blood flow (RBF) and mean arterial blood pressure (MABP) during experimental status epilepticus.
- To identify mechanisms responsible for altered hemodynamics during seizures.
Main Methods:
- Measurements of RBF and MABP in anesthetized, paralyzed rats during induced seizures.
- Intervention with renal denervation and bilateral adrenalectomy.
- Assessment of vascular response to norepinephrine.
Main Results:
- Initial seizures caused increased MABP and decreased RBF, which were mitigated by renal denervation or adrenalectomy.
- Late seizures showed decreased MABP and RBF, with blunted responses to norepinephrine.
- Renal nerves and adrenal glands mediate early RBF decreases.
Conclusions:
- Renal nerves or adrenal glands play a key role in reducing RBF during early seizures.
- Reduced vascular sensitivity to norepinephrine contributes to diminished MABP and RBF during later seizures.