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Updated: Jun 22, 2026

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Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Synthesis, in-vitro microbial and cytotoxic studies of new benzimidazole derivatives
Reddy S Harisha1, Kallappa M Hosamani, Rangappa S Keri
1P. G. Department of Studies in Chemistry, Karnatak University, Pavate Nagar, Dharwad, India.
Archiv Der Pharmazie
|June 12, 2009
Abstract:
Several new classes of benzimidazole derivatives were synthesized and evaluated for in-vitro antimicrobial and cytotoxic activities. The results showed that all synthesized compounds exhibited moderate antimicrobial activity, and compounds 2, 4, and 13 displayed cytotoxic activity (as LD(50)) at the concentration 1 x 10(-3) M against Artemia salina.
