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Updated: Jun 22, 2026

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
Published on: June 2, 2022
[Tophaceous calcium pyrophosphate dihydrate deposits in a finger]
1Service de rhumatologie, Département de médecine, Hôpital neuchâtelois, 2300 La Chaux-de-Fonds. daniel.vanlinthoudt@ne.ch
Abstract:
Calcium pyrophosphate dihydrate (CPPD) deposits are frequently observed in joint tissues. They can also occur in other tissues and present as a tophus. Contrarily to gout, a CPPD tophus is exceptionally localized in a finger. This presentation concerns a 81-year-old man who developed a huge tumor-like tophus of CPPD crystals on the antero-lateral side of his 3rd right finger, reducing superficial sensibility and eroding the proximal phalanx. Similarly to the majority of the rare previous reported cases, there was no associated chondrocalcinosis and the diagnosis was only made by the histological examination of the resected tissues. Better knowledge of this entity could avoid enlarged surgery as it has been done on some occasion.
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