Related Experiment Video
Updated: Jun 22, 2026

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.
Published on: May 6, 2010
Relations between Shannon entropy and genome order index in segmenting DNA sequences
1Department of Mathematics, Hebei University of Science and Technology, Shijiazhuang, Hebei 050018, People's Republic of China. zhaqi1972@163.com
Abstract:
Shannon entropy H and genome order index S are used in segmenting DNA sequences. Zhang [Phys. Rev. E 72, 041917 (2005)] found that the two schemes are equivalent when a DNA sequence is converted to a binary sequence of S (strong H bond) and W (weak H bond). They left the mathematical proof to mathematicians who are interested in this issue. In this paper, a possible mathematical explanation is given. Moreover, we find that Chargaff parity rule 2 is the necessary condition of the equivalence, and the equivalence disappears when a DNA sequence is regarded as a four-symbol sequence. At last, we propose that S-2(-H) may be related to species evolution.
Related Concept Videos
Evolutionary Relationships through Genome Comparisons
Entropy within the Cell
Organization of Genes
Organization of Genes
Entropy
Sanger Sequencing

