Receptor-mediated tumor targeting with radiopeptides. Part 1. General principles and methods

Area of Science:

• Nuclear oncology
• Radiopharmaceutical therapy
• Molecular imaging

Background:

• Radiolabeled peptides are vital tools in preclinical cancer research.
• They are utilized in nuclear oncology for diagnostic and therapeutic applications.
• Peptide radiopharmaceuticals represent a key aspect of molecular targeting strategies.

Purpose of the Study:

• To provide a comprehensive overview of receptor-mediated tumor targeting using radiopeptides.
• To summarize concepts, methods, and applications of radiopeptide targeting.
• To review the selection of radioisotopes, chelators, and peptide ligand development.

Main Methods:

• Literature review of receptor-mediated tumor targeting with radiopeptides.
• Summary of concepts and methods in radiopeptide targeting.
• Discussion of radioisotope selection, chelators, and peptide ligand criteria.

Main Results:

• Radiolabeled peptides are increasingly important for cancer research and therapy.
• Receptor-mediated targeting with radiopeptides is a developing field.
• The review covers diagnostic and therapeutic applications of peptide radiopharmaceuticals.

Conclusions:

• Advancements in radiopeptide research will expand their clinical utility.
• Peptide radiopharmaceuticals offer targeted approaches for cancer diagnosis and treatment.
• This review series provides foundational knowledge on radiopeptide targeting.